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Previously, Dryhurst and coworkers established that the mercapturate of dopamine and 5- S -cysteinyldopamine are potent neurotoxins

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However, instead of reacting with a second cysteine in Prx (i.e., the resolving cysteine), the sulfenic acid intermediate then condenses with a cysteine residue of a target protein forming an intermolecular disulfide (Fig