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Additionally, inflammatory cytokines aggravate cellular vulnerability to ferroptosis by blocking the cystine/glutamate antiporter system Xc – , which is necessary for cystine uptake for the synthesis of glutathione ( Ferroptosis produces neuroinflammation-increasing DAMPs such as HMGB1, ATP, and oxidized lipids

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Risk Factors Main risk factors for the condition include increasing age , diabetes mellitus , ischaemic heart disease , hypertension , and certain medications (beta blockers, proton pump inhibitors, antidepressants and antihistamines) There is an association between PD and those who suffer from Dupuytren’s contracture, however a genetic link is yet to be identified