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Research, including recent findings from the SELECT trial, indicates that GLP-1 agonists like semaglutide can significantly reduce the risk of major cardiovascular events, such as heart attacks and strokes, especially in individuals with obesity but without diabetes

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Likewise, there is preserved and rescued intestinal mucosal integrity and vein integrity, reversed portal hypertension along with recovery of bile duct ligation‐induced cirrhosis in rats (Sever et al., 2019), and reduced or even normal MDA levels in both ischemic and reperfusion conditions in various tissues (i.e., colon, duodenum, cecum, liver, and veins) and plasma (Amic et al., 2018