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Clinical Studies with IGFS and IGFBPs Recombinant human IGF-I (rhIGF-I) has been used with success to treat GH resistance and IGF-I deficiency syndromes in children, although clinical use is not widespread, in part because of metabolic adverse effects including hypoglycemia and hypophosphatemia

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Within adipose tissue and skeletal muscle, both major insulin responsive tissues, the intracellular concentration of glucose-6-phosphate is a direct function of the blood levels of both glucose and insulin