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If hair changes occur during use, investigate other causes

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6-8 A few epidemiologic studies have also found a correlation between increased hemoglobin levels and increased vaso-occlusive crisis (VOC) frequency, 9,10 and a phase 3 study of senicapoc (ICA-17043) was stopped early due to lack of efficacy in terms of reduction of VOCs despite an observed increase in hemoglobin and decrease in hemolysis