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TRX is a key antioxidant protein that reduces oxidative stress by catalyzing disulfide bond reduction in proteins, protecting cells from damage, and regulating redox-sensitive signaling with a possible immunomodulatory effect [47]

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Seventy-five patients with type 1 diabetes and various forms of autonomic neuropathy were enrolled in this study: 46 patients (mean age of 38.1 ± 12.5 years) were treated with intravenous ALA (600 mg/day) for 10 days, then with oral ALA (600 mg film tablet/day) for 50 days, while 29 patients (mean age 40.2 ± 9.3 years) served as the untreated control group