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Overt biotin deficiency is quite rare but has been documented in patients on prolonged intravenous feeding (parenteral nutrition) without biotin supplementation

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Scope and approach The method used in this research is a systematic review with the aim of research to determine the relationship between reactions during aging and changes in organosulfur, polysaccharides and non-enzymatic browning product compounds as well as the function of black garlic by focusing on certain aspects of aging including temperature, humidity, time, microorganism activity, and pre-treatment application