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It is important to note that the stimulation of GSK3β leads to phosphorylation of insulin receptor substrate protein 1 (IRS1) affecting insulin like growth factor 1 signaling (IGF-1) and resulting in downstream insulin resistance (Leng et al., 2010

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[8] focuses on commercial strategies for obtaining bio‐melatonin and also compares melatonin biosynthesis among animals and plants alongside yeast and algae, yet fails to provide details about microbial melatonin biosynthesis processes