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Thus, understanding transcriptomic and epigenetic regulation in astrocytes could clarify their precise role in neurodegenerative diseases and offer a potential pathway for leveraging their intrinsic heterogeneity to promote neuroprotection and counteract disease progression (Table 1)

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From flow cytometry analysis, we compared mitochondrial Ca 2+ levels using Rhod-2 AM, a high affinity calcium indicator that primarily localizes in mitochondria