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To infer a functional relationship between these conserved residues and GPX sequences, we searched for the known catalytic residues of model organism Arabidopsis GPXs in the UniProtKB/Swiss-Prot database of NCBI (www.ncbi.nlm.nih.gov/protein)

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As mentioned above, the traditional structural biology techniques X-ray crystallography and cryo-EM are not suitable for the analysis of highly flexible macromolecules existing as rapidly interconverting conformational ensembles