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AMPK is a major positive regulator of autophagy, which is activated by a high AMP-to-ATP ratio or by upstream kinases, such as LKB1 or CamKII (360, 361)

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In particular, the selection of an appropriate control or comparison group is required to determine, all other things being equal, whether a treatment is efficacious for a given illness, whether it has benefits over other therapies for the illness, and how it can achieve its effects