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Additional data have shown a correlation between diminished CD4+ T cell counts and increased levels of pro-inflammatory cytokines (IL-1β, IL-17, and IL-6) that contribute to systemic inflammation, and malondialdehyde (MDA), which is an end-product of lipid-peroxidation and a marker for oxidative stress

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GHK-Cu has been investigated for ECM remodelling, fibroblast and keratinocyte cellular pathway modulation, antioxidant chemistry, and gene-expression regulation, with the literature anchored by half a century of work since the original Pickart-laboratory characterisation