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Consequently, activation of these cascades leads to a reduction of the pro-inflammatory cytokine release, including tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), IL-1β, Il-17, IL-2, and interferon γ (INF-γ), the so called non-T helper cells 2 (Th2)-mediated cytokine profile (Figure 2), and reduction in adhesion molecule release including vascular cell adhesion protein 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and E-selectin

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AOD 9604 causes mild, transient nausea at most