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[DOI] [PubMed] [Google Scholar] Svenningsson AL, Stomrud E, Palmqvist S, Hansson O, Ossenkoppele R

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Nevertheless, since most of the caffeine in systemic circulation is normally eliminated within 4-5 half-lives (approximately 24 h) [38], it could be postulated that even multiple doses of coffee enemas (e.g., once a day or once every other day) would not result in the accumulation of caffeine in the body and hence should not adversely affect hemodynamic parameters