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The intricate balance of ROS and overall reduction of oxidative stress is extraordinarily important in heart tissue, as the cells that make up the heart have been estimated to have a renewal rate of 1% or less, depending on age (15)

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To critically appraise mechanisms and levels of evidence ( in vitro, in vivo , clinical) for vitamin E and C, glutathione and its precursors, polyphenols (quercetin, resveratrol, curcumin), Crocus sativus carotenoids (crocin/safranal), and “indirect” modulators (e.g., omega-3, folinic acid), emphasizing study quality, translational relevance, and limitations