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Published human data is limited to: • One 12-patient interstitial cystitis pilot (uncontrolled) • One 2-patient IV safety pilot (Lee and Burgess, 2025) • One cancelled 2015 Phase I trial (NCT02637284, never published) • One completed Phase II ulcerative colitis RCT of PL-14736 with results ONLY in a conference abstract Zero peer-reviewed randomized controlled trials (RCTs) exist for any indication

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This 43 amino acid peptide represents a synthetic fragment of Thymosin Beta 4, a protein naturally present in virtually every human and animal cell