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The role of interactions between tumor cells and components of the stroma, immune cells, or endothelial cells can influence the efficiency of metastasis, resulting in reduction, persistence, or progressive metastasis

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Noticeably, synaptamide, a DHA metabolite analog of the endocannabinoid anandamide, ameliorates cAMP signaling and boosts the NSC differentiation impaired by ethanol (Figure 2)