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Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren | Nature Communications

– Masking of folic acid deficiency: B12 supplementation may correct hematological abnormalities associated with folic acid deficiency while leaving neurological damage unaddressed

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Several interesting key findings of their study include: a) the cell death induction effect by curcumin was independently through p53 and caspase upregulation, which effectively dodge the atypical stimuli by both p53 and caspase that exert increased the survival and chemoprotection to tumor cells, b) the binding activities of AP-1 and NFκB were decreased (where the constitutively over-expression of these genes is a marker in GBM), c) curcumin decreased the expression of genes which conferred chemoresistance such as IAP and Bcl family, and d) the expression of DNA repair enzymes (MGMT, Ku70, Ku80 and DNA-PK cs ) believed to be involved in chemosresistance and radioprotection was inhibited by curcumin

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