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For example, when using RSL3—a canonical ferroptosis inducer through inhibition of GPx4—GPx1 cannot compensate for the loss of GPx4 since its main substrates are hydroperoxides whereas GPx4 reduces lipid peroxides [19]

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In both cases, Epitalon significantly enhanced telomerase activity, directly contributing to telomere elongation during the G1 phase of the cell cycle [ 25 ] [26 ]