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On one or both edges of the 20S core, various regulatory complexes may be bound giving rise to higher molecular weight complexes with the 26S/30S proteasome being the most studied (produced through binding of one (26S) or two (30S) 19S complexes at the 20S core ends) (Ciechanover 1998

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It initiates a self-limiting healing process, but imbalances lead to chronic inflammation, causing cellular and tissue damage and it can aggravate into several chronic inflammatory disorders, including rheumatoid arthritis (RA) 2,3,4