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These tests include the large fiber nerve injury tests (electrodiagnostic tests: nerve conduction tests and electromyography) and the small fiber nerve injury (intraepidermal nerve fiber density) (6, 7, 74) ( Figure 1 )

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Production and purification of recombinant proteins The constructs corresponding to human FOXO4 (residues 86 – 206) and human p53 (residues 1 – 312), were purchased from Genscript in a pUC cloning vector