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Polyamines — putrescine, spermidine, and spermine — are polycationic molecules synthesized from arginine and S-adenosylmethionine (SAM)

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While apoptosis is induced by p53 through activating pro-apoptotic genes, levels of p53 increase by silymarin treatment in a dose dependently manner which leads to cytochrome C release, activating many pro-apoptotic genes such as APAF-1 and caspase-9