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A 2018 review by Pickart and Margolina documented that GHK-Cu affects the expression of more than 4,000 human genes (roughly 31 percent of the genome), generally shifting expression patterns toward younger, more regenerative profiles

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A 2-year observational study that included 168 CKD patients demonstrated that participants with the lowest vitamin D levels had a faster rate of CKD progression and shorter time to kidney failure and death