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Mechanism rationale and its limits The mechanism rationale for cagrilintide-plus-tirzepatide: Tirzepatide activates GLP-1 and GIP receptors Cagrilintide activates amylin and calcitonin receptors The two drugs operate through different signaling pathways Combining them should theoretically engage more appetite-control pathways than either alone The limits: First, additive mechanism does not guarantee additive clinical effect

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