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Other studies have shown that HT generates ROS and activates the phosphatidylinositol 3-kinase/Akt pathway, leading to FOXO3a(Forkhead box O3) phosphorylation and subsequent down-regulation, which induces apoptosis in DLD1 cells 31

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It has been shown that copper induces the production of IL-6 in fibroblasts and keratinocytes, and in various studies it was documented that the intensity of the inflammatory response is related to the systemic/ tissue concentration of copper [92,93,94,95]