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In recent years, more and more studies have confirmed that TLRs expressed in tumor tissues with different subtypes of TLRs, such as gastric cancer, 23,24 colorectal cancer, 25,26 ovarian cancer, 27 lung cancer, 28 prostate cancer, 29 breast cancer, 30,31 liver cancer 32,33 and pancreatic cancer, 34 which were actived by different ligands playing an important role in the occurrence and development of tumor