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In the case of animals inoculated peripherally with scrapie, the agent propagates along peripheral sensory and autonomic nerves in the peritoneum to enter the spinal cord and medulla, and then ascends to invade the brain (Kimberlin and Walker, 1982)

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That means a thorough footwear audit — replacing worn-out shoes, ditching completely flat footwear for anything involving significant walking, and modifying activities that load the injured tissue before it's ready