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Early warning signs of hypoglycemia may be less obvious in patients with hypoglycemia unawareness which can be due to a long history of diabetes (where deficiencies in the release or response to counter regulatory hormones exist), with autonomic neuropathy, intensified diabetes control, or taking beta-blockers, guanethidine, or reserpine

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Because preclinical reports describe activity on fat-cell metabolism without stimulating IGF-1 production, AOD-9604 is studied as a way to separate GH's metabolic effects from its growth-promoting effects