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Overall, a multi-faceted approach is necessary for risk assessment of reactive metabolites

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140,141,142,143,144 Targeting autocrine/paracrine, and systemic functions: therapeutic considerations GHR antagonism suppresses the endocrine, autocrine, and paracrine functions of GH, and this is an important consideration that has particular relevance for cancer on the basis that both systemic and tumor-derived GH contribute to cancer progression