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The benefits of Resveratrol had been proven through diverse models, as in diabetic mice along the NRF-2/HO-1 pathway [101], as well as a better glucose and lipid profile through the activation of Keap-1/NRF-2 [102]

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The authors conclude that this antioxidant-based support is well tolerated and may provide clinically meaningful benefits, although controlled trials are needed to confirm efficacy ( Weight of evidence: Overall evidence is Low : primarily preclinical with heterogeneous designs and no consistent human biomarkers