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PT-141 (bremelanotide) and PT-141 nasal spray formulations have specific stability requirements depending on formulation

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Biochemical assays in the acute gout rat model The serum levels of interleukin-1α (IL-1α), IL-1β, interleukin-6 (IL-6), interleukin-8 (IL-8), IL-10, interleukin-16 (IL-16), C-X-C motif chemokine 10 (CXCL10), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1α (MIP-1α), interferon gamma (IFN-γ), TNF-α, tumor necrosis factor-β (TNF-β), nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), 6-keto-prostaglandin F-1α (6-Keto-PGF1α) and prostaglandin E2 (PGE2) in rats were determined by the ELISA method using related Elisa Kits (Yuanye Bio-Technology, Shanghai, China) according to the manufacturer’s instructions

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