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Activation of Nrf2 in tumors is unlikely to be a cancer-initiating event but rather a result of selection during tumor development, because Keap1 KO mice with elevated Nrf2 functions did not develop spontaneous cancer over a 2-year period (167)

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PD-1, associated synergistic genes inserted into the HSV genome, include single, stranded variable fragment PD-1 (ScFvPD-1), variable region components of antibodies targeting programmed death receptor one (anti-PD-1 Fab),and portions acting as PD -1 blockers (PD-L1B)

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