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In ovalbumin (OVA) and house dust mite-induced asthma models, pulmonary Acod1/Irg1 expression and itaconate levels are markedly upregulated, whereas Acod1-deficient mice exhibit exacerbated type II inflammation, including elevated IL-5/IL-13, increased serum IgE, enhanced eosinophil infiltration, and worsened airway hyperreactivity

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(157) have reviewed forty one articles including major RCTs that have studied the effect on NAC on respiratory conditions including chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, bronchiectasis, chronic bronchitis and cystic fibrosis with respect to the side effects of NAC at doses between 600 mg per day to 3,000 mg per day