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Daily or three consecutive ibuprofen treatments (on days 1+2+3) potently repressed both IgM and IgG synthesis whereas ibuprofen exposures late in culture (days 4+5+6) had relatively little effect on antibody synthesis

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Instead, it acts through hypothalamic thermoregulation, gently lowering core body temperature before sleep onset.¹ Clinical studies demonstrate that individuals taking 3 grams approximately one hour before bedtime frequently experience: Faster sleep onset Improved sleep efficiency Better REM sleep architecture Reduced daytime fatigue Improved cognitive performance the following morning¹˒² This mechanism closely resembles the natural physiologic temperature decline that precedes restorative sleep