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FIGURE 2 2.2 Mitochondrial dysfunction caused by oxidative stress in diabetes Mitochondria, also known as the “energy house” [39], are highly dynamic double-membrane organelles that produce adenosine triphosphate (ATP), the energy that the body requires (Newmeyer and Ferguson-Miller, 2003)

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Metabolic state-driven approach involves identifying and quantifying intracellular metabolites and the anabolic and catabolic biochemical pathways by which they are interconverted and interrelated 12,25,26,27,28