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For SSD, the picture is somewhat different: Both low (baseline) IQ and a decline in cognitive functioning have been associated with increased risk of SSD in individuals with 22q11DS, with the strongest effect size for a decline in Verbal IQ [3, 99, 100], largely converging with findings for idiopathic schizophrenia [101,102,103]
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This might initially seem counterintuitive, but controlled matrix degradation is essential for tissue remodeling and replacement of damaged structural proteins with newly synthesized, functional equivalents