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documented that atorvastatin induces a substantive downmodulation of RhoA abundance in murine models of diabetes mellitus, specifically within the pathophysiological milieu of diabetic nephropathy [187].The chronic inflammatory environment in diabetic patients is in part facilitated by the NF-κB cascade [188], which is triggered by free fatty acid (FFA)-induced inflammation and glucolipotoxicity (increased glucose and lipid levels) and lead to beta islet cell dysregulation [189]