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showed that the administration of agmatine in BDL rats for seven days after bile duct ligation was able to reduce ROS and nitric oxide formation and lipid peroxidation, and to increase mitochondrial GSH both in the liver and in the kidney in a dose-dependent way [200]

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AOD-9604 failed to produce statistically significant fat loss versus placebo in the only multi-dose human RCT conducted, testing doses from 1 mg to 30 mg daily over 12 weeks