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This quantitative understanding is now driving the development of pathway-specific inhibitors, such as PKC-β selective antagonists, SGLT2 inhibitors, and glyoxalase-1, which have shown promise in preclinical models for breaking this cycle without globally suppressing physiologically important ROS signaling -Figure 3 (Oliveira et al., 2023

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Gln is transported to cells where it acts as a starting material for the production of different amino acids, proteins, nucleotides, and other important biological molecules