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Quillinan et al., 2011) suggests that the affinity of the β- arrestin2 association to MOR is relatively weak (Oakley et al., 2000), so that it can dissociate rapidly prior to endocytosis, thereby exposing the phosphorylated C-terminal residues (Ser375, Thr370, and presumably others) to phosphatases

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Factors such as dosage, formulation, sun exposure, diet, and existing pigmentation can influence the timeline