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The AAFP’s evidence-based clinical review states directly: “Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency” (Langan RC, Goodbred AJ, American Family Physician, 2017)

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The rate-limiting enzyme GR which mediates the AsA–GSH cycle ensures elevated AsA concentrations in the vacuoles to easily scavenge phenoxy radicals [64]