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In combination with curcumin, BBR regulates the miR-221/ SRY-box transcription factor 11 (SOX11) axis to activate pro-apoptotic proteins caspase-3/9, promoting apoptosis in HCC cells and exerting anti-hepatocarcinoma effects (Li et al., 2023[98])

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It is a short, focused protocol of 10 daily injections, with 4 months between cycles and a maximum of 3 cycles per year

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