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For athletes and body-recomp goals, the signal is promising , but evidence-based protocols require human trials to confirm efficacy, safety, and optimal integration with training/nutrition

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Similarly, pharmacological inhibition of HSL and knockdown of PNPLA2 reduced the expression of known PPAR target genes in which LDs were shown to be a source of PPARα and PPARδ ligands that could be generated within minutes of stimulating lipolysis (3)