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Additionally, risk factors such as obesity, T2DM, chronic inflammation, and gut microbiota dysbiosis exacerbate oxidative stress, further promoting disease progression (Figure 1) [3,17,63]

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“Systematic Review and Pragmatic Clinical Approach to Oral and Nasal Vitamin B12 (Cobalamin) Treatment in Patients with Vitamin B12 Deficiency Related to Gastrointestinal Disorders.” Journal of Clinical Medicine , 2018;7(10):304

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