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Cancer: dual roles in initiation, progression and therapy response In cancer, ROS are Janus-faced: during initiation, oxidative DNA lesions (e.g., 8-oxoG, single-/double-strand breaks) and lipid-derived electrophiles from peroxidation increase mutational burden and clonal selection (O’Reilly et al

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While CB-839 inhibited the proliferation of patient-derived glioma cell lines, it did not affect cell viability (103).In NSCLC, KEAP1 mutant NSCLC cell lines exhibit a dependence on Gln, and the GLS inhibitor CB-839 can inhibit Gln metabolism to exert anti-tumor effects (104)