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PMID: 11713213 View source Stier H, et al
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The relationship between immune function and nutritional supplementation is a well-described phenomenon.4-7 Numerous studies have reported a high prevalence of nutrient deficiencies early in the course of HIV infection.8-10 These deficiencies have been shown to be associated with more frequent opportunistic infections, faster disease progression, and a greater incidence of HIV-related mortality.11-15 Possible mechanisms include increased intracellular oxidative stress, enhanced viral replication, and a reduction in the number of circulating CD4 lymphocytes associated with individual or accumulated nutrient deficiencies.14-18 These mechanisms, alone or in part, may contribute to the increased morbidity, more rapid disease progression, and the higher mortality seen in HIV-infected patients with nutrient deficiencies.18-21 Several prospective, randomized clinical trials now suggest that HIV-infected patients who take micronutrient supplements have improved clinical outcomes
