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Cardioprotection / tissue protection — preclinical GH secretagogues including GHRP-6 have an animal and cell literature on protecting heart and other tissue from injury

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Neh4 and Neh5 have been shown to represent Nrf2 transactivation domains, which act cooperatively in binding the coactivator CREB binding protein, thereby synergistically increasing the rate of gene transcription [72]