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In experimental AP, activation of PINK1/Parkin-dependent mitophagy has been associated with inhibition of NLRP3 inflammasome signaling and attenuation of inflammatory activity in PACs ( Electron microscopy studies have demonstrated that, as early as 1–2 hours after AP induction, numerous autophagosomes and autophagolysosomes containing mitochondrial remnants appear in PACs, indicating rapid activation of mitophagy ( Available data also suggest stage-dependent effects

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