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Furthermore, according to functional studies in a mouse model, IFN-γ, inteferon-gamma receptor (IFNgR), signal transducer and activator of transcription protein 1 (STAT1), C-X-C motif chemokine ligand 10 (CXCL10), and C-X-C motif chemokine receptor 3 (CXCR3) are also critical for developing hypopigmentation in vitiligo (46, 107, 110)

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This is an active, energy-intensive process