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You can make finer dose adjustments (like stepping from 0.5 mg to 0.75 mg instead of jumping straight to 1.0 mg) and you can use split dosing strategies that pre-filled pens do not allow

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The pathogenesis leading from CKD to cardiovascular disease in GPX3-/- mice is thought to be from the significant oxidative stress promoted by CKD leading to endothelial dysfunction, decreased NO, and consequential vascular disease and thrombosis [41]